The invention discloses a rolling method of a biodegradable medical Zn-Li alloy and belongs to the technical field of biodegradable medical materials and metal rolling. The method includes: homogenizing alloy ingots: rising temperature to 200-280 DEG C at a speed of 2-6 DEG C per min, holding the temperature for 1-2h, rising the temperature to 300-380 DEG C at a speed of 0.5-1 DEG C per min, holding the temperature for 1-2h, and cooling along with a furnace; after alloy is preheated, hot rolling: putting the alloy back into the furnace and holding the temperature for 10-20min after the secondtime of rolling, and quenching in water after the fourth time of rolling, wherein rolling start temperature is 300-380 Deg C, press-down amount of each time of rolling is 25-40%, and rolling is performed for four times in total; warm rolling: rolling once, and quenching in water, wherein rolling start temperature is 60-250 DEG C, and press-down amount is 50-70%. Through a simple rolling process, the biodegradable Zn-Li alloy with high strength and high plasticity is obtained, the problem of low section plasticity caused by common plastic processing methods is avoided, and material using requirements of various human implantation devices are met. The method is low in cost and easy for large-scale production in factories, thereby having extremely high popularization value and extensive application prospect in the field of medical materials.