The invention relates to a PVF/B self-adhesion transposition wire and a manufacturing method thereof and belongs to the transformer winding wire manufacturing technology field. According to the method, a flat copper conductor is employed to cover a PVF/B insulation paint layer, an epoxy self-adhesive paint layer is coated, PVF/B self-adhesive enameled flat copper wires are formed, the multiple PVF/B self-adhesive enameled flat copper wires are braided and combined to form a transposition wire harness, and multiple B-level insulation paper layers are utilized to externally cover the transposition wire harness to acquire the PVF/B self-adhesion transposition wire. The method is advantaged in that the prepared transposition wire is suitable for UHV AC and UHV DC transformers and transformer windings mounted in areas with high environment temperatures, the insulation heat resistance grade can be enhanced by 10 DEG C, and the life can be prolonged by 10 years.