The invention relates to an insulated and weather-resistant electronic connection wire. The insulated and weather-resistant electronic connection wire comprises a conductor and an internal insulationlayer, wherein the internal insulation layer wraps the conductor, a fireproof mica tape is arranged between the conductor and the internal insulation layer, an external insulation layer is arranged outside the internal insulation layer, a fireproof oxygen isolation layer is arranged between the internal insulation layer and the external insulation layer, the thickness of the fireproof mica tape is0.1-0.12 millimeter, the thickness of the fireproof oxygen isolation layer is 0.6-1.2 millimeters, a water blocking layer is arranged between the external insulation layer and the fireproof oxygen isolation layer and comprises three water blocking yarns, water blocking powder is filled among the water blocking yarns, and the thickness of the water blocking layer is 0.1-0.2 millimeter. The fireproof mica tape is arranged between the conductor and the insulation layer, no volatilization of harmful smoke exist during combustion with an open fire; the fireproof oxygen isolation layer is arrangedbetween the insulation layer and the external insulation layer, an acid gas can be effectively prevented during combustion when a fire occurs; a waterproof layer is further arranged on the connectionwire, and a relatively good waterproof effect is achieved; and the insulation layer and the fireproof oxygen isolation layer employ a special formula design, and the effect is better.