The invention discloses a method for constructing 2,4-diaryloxazole by acetophenone compound, ammonium persulfate and dimethylsulfoxide jointly. The method includes that the acetophenone compound is subjected to cyclization reaction in DMSO (dimethylsulfoxide) solution which contains ammonium persulfate and TBAI (tetrabutylammonium iodide) to obtain 2,4-diaryloxazole. According to the method, thecheap acetophenone compound, ammonium persulfate, dimethylsulfoxide and the like are used as raw materials for one-pot high-yield synthesis of 2,4-diaryloxazole compounds under mild reaction conditions without heavy metal or precious metal catalytic action, and industrial production is benefited.