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发明授权
CN108440636B 一种CDDO-Me衍生物、制备方法及医药用途 有权

一种CDDO-Me衍生物、制备方法及医药用途
摘要：
本发明公开了一种CDDO‑Me衍生物、制备方法及医药用途。本发明针对CDDO‑Me毒副作用较大的不足，提供了一种CDDO‑Me衍生物。抗炎活性测试显示：与CDDO‑Me相比，本发明提供的CDDO‑Me衍生物具有类似活性强度的抗炎作用；细胞毒试验测试显示：与CDDO‑Me相比，本发明提供的CDDO‑Me衍生物在对RAW 264.7巨噬细胞显示了更低的增殖抑制作用，毒性更低，安全性更高。因此，本发明提供的CDDO‑Me衍生物可以用于制备成安全性更高的抗炎药物用于防治炎症相关疾病，如急性肺损伤、肺动脉高压、糖尿病肾病。本发明还提供了CDDO‑Me衍生物的制备方法，条件温和，步骤少，可实施性强。
摘要（英）：

The invention discloses a CDDO-Me derivative, a preparation method and medical application. In view of the shortcoming that CDDO-Me has strong toxic and side effects, the invention provides the CDDO-Me derivative. An anti-inflammatory activity test shows that compared with the CDDO-Me, the CDDO-Me derivative provided by the invention has the anti-inflammatory action at the similar activity intensity; and a cytotoxic activity test shows that compared with the CDDO-Me, the CDDO-Me derivative provided by the invention is lower in proliferation inhibition effect on RAW 264.7 macrophage, lower in toxicity and higher in safety. Therefore, the CDDO-Me derivative provided by the invention can be used for preparing an anti-inflammatory drug with higher safety to prevent and treat inflammation-related diseases, such as acute lung injury, pulmonary arterial hypertension and diabetic nephropathy. The invention further provides the preparation method of the CDDO-Me derivative. The conditions are mild, the number of steps is small, and the practicability is high.

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