The invention discloses high-acid-solubility plugging liquid during drilling. The high-acid-solubility plugging liquid during drilling is prepared from the following components in percentage by weight: 2-4% of aluminum alloy particles GYD, 3-5% of flexible polymer materials, 4-5% of superfine calcium and the balance of drilling fluid. The high-acid-solubility plugging liquid during drilling has anacid solubility rate of 80% or higher, and can be used in oil-based drilling fluid. The high-acid-solubility plugging liquid during drilling further has a relatively good bridge plugging function anda relatively good filling function, and has a very good plugging effect for pore and seam type leakage.