The invention relates to the field of natural medicine, in particular to compound phytolectin and a preparation method and application thereof. The compound phytolectin is prepared from pseudo-ginseng, eucommia ulmoides, root of kudzu vine, rehmannia, root of red-rooted salvia, kelp and silverweed cinquefoil root leaves, wherein the compound phytolectin contains the components of salvianic acid, salvia miltiorrhiza flavones, notoginsenoside, rehmannia saponin, rehmannin, laminaran, pueraria flavones and eucommia ulmoides terpene. Pharmacological experiments prove that the compound phytolectinhas an ideal therapeutical effect for hypertension, when the compound phytolectin is cooperatively used with hypotensive drugs, the antihypertensive efficacy is further strengthened and is obviously superior to exclusive use of hypotensive drugs, and the toxic and side effects such as edema of hypotensive drugs after cooperative use are greatly reduced. Moreover, the compound phytolectin is a natural preparation, is safe and reliable to use, is applicable for various types of hypertension patients, and is extremely suitable for current clinical requirements.