The invention discloses a compound traditional Chinese medicine material composition, a compound traditional Chinese medicine and a compound traditional Chinese medicine preparation for curing post-stroke depression and preparation methods. The compound traditional Chinese medicine material composition is prepared from turmeric, radix bupleuri, herba hyperici perforati, ginseng and astragali radix. The prescription medicines are used in cooperation, the functions of promoting the blood, dispersing the liver, resolving depression, dredging the collaterals, tranquilizing the mind by nourishing the heart, invigorating the spleen to remove phlegm are achieved, and the preparation is used by a patient suffering from post-stroke depression which belongs to stagnation of the liver qi and the syndrome of intermingled phlegm and blood stasis. The pharmacodynamics research of the compound traditional Chinese medicine extracted from the compound traditional Chinese medicine material composition shows that the compound traditional Chinese medicine has the effects of obviously improving the depression symptoms of depressed mice and rats suffering from post-stroke depression, protecting the cranial nerves and obviously warding against depression and post-stroke depression. The clinical effect result shows that the compound traditional Chinese medicine material composition, the compound traditional Chinese medicine and the compound traditional Chinese medicine preparation for curing post-stroke depression have the efficacy of promoting the blood, dispersing the liver, resolving depression, dredging the collaterals, tranquilizing the mind by nourishing the heart and invigorating the spleen to remove phlegm, can effectively improve various traditional Chinese medicine symptoms of the patient suffering from stagnation of the liver qi and the syndrome of intermingled phlegm and blood stasis, ward against depression and improve the neurological function and has no obvious adverse drugreactions.