The invention discloses an automatic cleaning device for an optical fiber splice, and solves the problem that the optical fiber splice is liable to be worn because of being wiped by a solid such as dust-free cotton or an alcohol pad, and then light attenuation is caused. The automatic cleaning device disclosed by the invention comprises a housing and a groove located in the housing and matched with the optical fiber splice, wherein the groove is internally held with alcohol; an ultrasonic device, a pressure sensor and a control device are further arranged in the housing; the ultrasonic deviceis located on the back surface of the groove and makes contact with the groove; the control device is connected with the ultrasonic device and the pressure sensor separately, and the pressure detectedby the pressure sensor is increased with the downward movement of the optical fiber splice; and the control device increases an ultrasonic power according to the received pressure information, and then adjusts the cleaning efficiency and effect for the optical fiber splice. The automatic cleaning device disclosed by the invention has the advantages of preventing the optical fiber splice from being worn, and being good in cleaning effect, capable of being automatically started up and stopping cleaning, and the like.