The invention provides a large-sized wheel manual assembling and disassembling device. The large-sized wheel manual assembling and disassembling device comprises a U-shaped base; the U-shaped base consists of two cantilevers vertically and symmetrically connected to the two ends of a cross beam in a fixed manner; the U-shaped base is connected with a hydraulic lifting device; two distance adjustable sliding arms are arranged on the cross beam; the sliding arms are parallel to the cantilevers; rotating rollers are arranged on the internal sides of the sliding arms; pull rod brackets are arranged at the connecting parts between the cantilevers and the cross beams; vertical pull rods are arranged in the pull rod brackets; the vertical pull rods freely expand and retract in the pull rod brackets; transverse pull rod fixing sleeves are arranged at the tops of the vertical pull rods; and L-shaped transverse pull rods are arranged in the transverse pull rod fixing sleeves. According to the large-sized wheel manual assembling and disassembling device provided by the embodiment of the invention, as a wheel axle positioning and circumferential positioning part is mounted on the U-shaped base, and the U-shaped base is lifted and lowered by using the hydraulic lifting device, the disassembling, assembling and conveying of a large-sized wheel can be finished by a single person without external power; and therefore, the operation process of the large-sized wheel manual assembling and disassembling device is safe and convenient, and the large-sized wheel manual assembling and disassembling device can be used for production line assembling, maintenance station maintenance and outdoor use.