The invention provides a substation five-prevention verification method based on switching principle. The method comprises the following steps: S1) drawing a main wiring diagram of primary equipment of a substation; S2) carrying out model analysis on the main wiring diagram of the primary equipment to obtain an equipment model; S3) according to five-prevention rules, determining the switching principle of each type of operating equipment, and defining unlock state of condition equipment based on the switching principle; S4) when operating the operating equipment, searching in the equipment model to obtain the condition equipment; and S5) judging whether the real-time state of the condition equipment meets the unlock state, and if so, allowing operation, and if not, forbidding the operation. The method avoids manual work of defining logical conditions for each specific device in the substation and prevents the risk of making errors in manually defining the logical conditions.