利索-全球专利检索

  1. 登录
  2. 注册
发明授权
CN108503617B 一种光学纯(R)-6-甲氧基苯并二氢吡喃-3-羧酸的制备方法 失效 - 权利终止

一种光学纯(R)-6-甲氧基苯并二氢吡喃-3-羧酸的制备方法
摘要：
本发明公开了一种光学纯(R)‑6‑甲氧基苯并二氢吡喃‑3‑羧酸的制备方法。具体步骤如下：往外消旋的6‑甲氧基苯并二氢吡喃‑3‑羧酸中，加入乙腈和解拆剂，加热回流状态下，滴加醇直至溶液澄清，经降温、结晶、分离后，得到铵盐复合物，随后用酸将上述铵盐复合物酸解，游离出光学纯的(R)‑6‑甲氧基苯并二氢吡喃‑3‑羧酸；再对所得(R)‑6‑甲氧基苯并二氢吡喃‑3‑羧酸进行重结晶，得到高光学纯的(R)‑6‑甲氧基苯并二氢吡喃‑3‑羧酸。本发明制备方法具有原料廉价易得，条件温和，合成工艺简单、解拆剂可循环利用、成本低等优点。
摘要（英）：

The invention discloses a preparation method of optically pure (R)-6-methoxychroman-3-carboxylic acid. The preparation method specifically comprises the following steps: adding acetonitrile and a decomposition agent into racemic 6-methoxychroman-3-carboxylic acid, dropwise adding ethanol at a heating reflux state until the solution is clarified, carrying out cooling, crystallization and separationso as to obtain an ammonium salt compound, carrying out acidolysis on the ammonium salt compound by virtue of acid so as to dissociate optically pure (R)-6-methoxychroman-3-carboxylic acid; and carrying out recrystallization on the obtained (R)-6-methoxychroman-3-carboxylic acid, so as to obtain high-optically pure (R)-6-methoxychroman-3-carboxylic acid. The preparation method has the advantagesthat the raw materials are cheap and easily available, conditions are mild, a synthetic process is simple, the decomposition agent can be circularly utilized, the cost is low, and the like.

公开/授权文献
0/0