The invention discloses an intelligent transformer substation bus protection configuration control CRC calibration method and device. The method comprises the steps that total virtual terminal verification codes of bus production are generated, and process layers of all interval equipment of bus production receive and send the virtual terminal verification codes; a CRC calibration module performscomparison calculation on corresponding verification codes generated before and after an intelligent transformer substation changes, and aiming at the inconsistent parts of CRC verification codes, theprocess layers of the changed interval equipment are determined. Accordingly, on the basis of an original virtual terminal verification code of bus production, the process layers of all the intervalequipment of bus production are additionally arranged to receive and send the virtual terminal verification codes, the process layers of the changed interval equipment can be determined accurately, that is to say, an interval circuit of on-site verification needs to be carried out, potential risk situations such as mistaken modification and wrong modification are found in time, the test range is narrowed down, the integrity and consistency control level of configuration files is improved, the workload of field staff is reduced, and the bus differential control work efficiency and reliability are improved.