The present invention discloses a regional power grid risk early warning method based on multi-dimensional evaluation indexes. The method comprises the steps of: establishing regional power grid riskevaluation indexes based on device overload, N-1 loss of load, a weak shipment party and automatic bus transfer lock, employing real-time operation information of a power grid to analyze influences ofvarious risk indexes, scanning risk points of the power grid, simulating and analyzing the power grid change conditions after the risk points are disconnected, wherein the conditions comprise newly added out-of-limit device, outage devices, voltage loss factory stations, outage users and loss load information, and finally, giving a risk grade evaluation result based on a quantization grading rule. The regional power grid risk early warning method is suitable for multi-dimensional risk evaluation of operation features of the regional power grid, can timely and comprehensively analyze the weaklinks of the regional power grid and provides assistant suggestion for analysis, decision, arrangement of shipment parties and load transferring by dispatching personnel so as to provide defense and improve measures and practically improve the power grid emergency disposition efficiency and the ability for withstanding emergency risks.