The present application relates to the technical field of communications, and specifically disclosed thereby are a method, device and equipment for calibrating an antenna. The method comprises: a base station acquiring a first downlink calibration signal returned by a coupler of a reference antenna of the base station; the base station acquiring a first uplink calibration signal from an uplink reference channel of the reference antenna by means of the coupler; the base station determining a calibration coefficient of the reference antenna according to the ratio of the acquired first downlink calibration signal to the acquired first uplink calibration signal; the base station acquiring a second downlink calibration signal by means of an antenna to be calibrated; the base station acquiring a second uplink calibration signal sent by the antenna to be calibrated; the base station determining a calibration coefficient of the antenna to be calibrated according to a ratio of the second downlink calibration signal to the second uplink calibration signal and the calibration coefficient of the reference antenna; and the base station compensating a radio frequency response for an uplink channel or downlink channel of the antenna to be calibrated according to the calibration coefficient of the antenna to be calibrated.