The invention discloses an expressway vehicle safety running and chain-reaction collision prevention alarm device. The device comprises a safety fuse box, and the safety fuse box is composed of a cardcase and an alarm system in the card case; a suction cup device is arranged on the safety fuse box for being sucked to a front windshield inside a vehicle; the alarm system comprises a camera, a processor, a GPS positioning device, an image processing module, a wireless transceiving device, a voice module, a display screen, a storage and a power module. The technology is simpler, manufacturing iseasy, and operation is convenient; by adopting the safety fuse box, expressway vehicle chain-reaction collision accidents are avoided basically.