The invention provides a power-off protection device, a using method thereof and power supply equipment. The power-off protection device comprises a switch module, a self-locking module, a control module and a power supply module, the control module is electrically connected with the switch module, the self-locking module and the power supply module, the AC input end of the self-locking module isconnected with an AC live wire, and the self-locking module is connected with the control module and the power supply module; the switch module forms a first or second triggering signal when being pressed down; the self-locking module forms self locking according to the first triggering signal, provides a voltage of the AC wire to the AC output end of the self-locking module, and controls power off according to the control module; when the self-locking module forms self locking, the control module controls the power supply module in a load power supply mode, and under control of the switch module, the control module stops the power supply module from supplying power, and the control module can power off the self locking module according to the second triggering signal; and he power supplymodule is in the load power supply module according to control of the control module. The intelligent degree is higher, and the practicality is higher.