The invention discloses an optoelectronic isolation device with a calibration function. The device comprises an electro-optic modulator used for converting an input voltage signal into a current, anddriving a laser tube to output an optical signal in direct proportion to the input voltage; an optic-electro converter used for converting the input optical signal into a voltage signal; a calibrationsignal output module used for outputting a standard electrical signal; and a filtering module used for performing filtering treatment on the electrical signal output by the optic-electro converter. According to the device and method provided by the invention, the defects of the prior art can be improved, and thus the optoelectronic isolation device can be quickly calibrated.