The invention provides a method for creating new azalea germplasm by combining distant hybridization and tissue culture at high efficiency. The method comprises the following steps of using Dongjuan series variety (Yanzhimi) as a male parent, using Chunjuan series variety (Chunwubao) as a female parent, hybridizing, collecting the capsule after hybridizing at the current year, stripping seeds, developing a sterile seedling with 7 to 10 buds and height of about 8 to 10cm by a special tissue culture technique, and performing subculture rooting, so as to obtain four to six times of propagation coefficient. Compared with the traditional field cuttage or grafting propagation (20 or less of propagation coefficient within one year), the method can greatly shorten the breeding cycle of the novel variety.