The invention discloses a modified hot melt polyurethane resin adhesive which comprises the following raw materials in parts by weight: 6-60 parts of modified polyurethane resin, 2.5-30 parts of copolymer of methyl methacrylate and butyl acrylate, 2.7-9.6 parts of epoxy soybean oil, 1.2-6.5 parts of barium stearate, 2.5-10 parts of paraffin, 1.7-5 parts of copper dialkyldithiophosphate and 5-10 parts of white carbon black. The adhesive has higher viscosity, and excellent initial and permanent adhesion and heat stability.