The invention discloses an anti-radiation and high-wear-resistance flexible cable, which consists of a conductor, an insulating layer, a composite main shield, a wrapping layer and a sheath layer frominside to outside, wherein the conductor is formed by stranding multiple strands of silver-coated annealed copper wires; the insulating layer is made of a crosslinked ethylene-tetrafluoroethylene copolymer; the composite main shield is formed by twisting an aluminum-plastic composite thin film and a silver-coated annealed copper wire; the wrapping layer is formed by wrapping a layer of halogen-free flame-retardant high-temperature-resistant woven belt; and the sheath layer is made of KEVLAR aramid yarn. The anti-radiation and high-wear-resistance flexible cable can meet the requirement for electrical property and also can meet high-temperature resistance, small size, light weight, flame retardancy, high wear resistance and chemical stability. The cable can keep the specific flexibility and high dielectric strength in extremely complicated and severe environments with various rays and ultraviolet radiations in the aerospace field.