The invention discloses a weight-based hybrid integer quadratic programming multi-target scheduling method. According to the method, coal consumption, network loss, emission and electricity purchasingcost are taken as multiple reference targets for scheduling, from the perspective of conversion, according to the weight of the different targets, a multi-target problem is converted into a single-target problem for solution, and thereby solution complexity of an original multi-target optimization model is reduced, and stability and robustness of the single-target solution algorithm can be utilized to the large extent.