The invention discloses a power grid regulation method and device based on artificial intelligence. The method comprises the following steps: acquiring historic databases of the power grid and the current weather data, wherein the historic databases comprise a historic load database, a historic weather database, a historic power generation plan database, and a historic security measure arrangementdatabase; calling a first neural network, transmitting the historic databases and the current weather data to the first neural network, and computing to obtain a first power generation plan and a first security measure arrangement; calling a second neural network, transmitting the historic power generation database and the first power generation plan to the second neural network, and computing toobtain a second power generation plan; and calling a third neural network, transmitting the historic security measure arrangement database and the first security measure arrangement to the third neural network, computing to obtain a second security measure arrangement. Through the power grid regulation method disclosed by the invention, the accurate power generation plans and the immediate security measure arrangement can be provided according to the historic data and the current data, thereby guaranteeing the stable and safe running of the power grid.