The invention relates to the technical field of communication, and discloses a practical interference alignment and deletion method comprising the steps as follows: interference alignment precoding oftwo sending nodes is designed, so that the interference of the two sending nodes to two unexpected receiving nodes is separately combined into the same signal sub-spaces of the two receiving nodes; the precoding of the other sending nodes is designed by using interference alignment, so that the two receiving nodes decode respectively expected data; the two receiving nodes acquiring the data transmit the decoded data to the third receiving node via a return link; and the third receiving node decodes the respectively expected data and the data of the residual receiving nodes, which are not decoded, via the return link, and then the third receiving node transmits the corresponding expected data to the residual receiving nodes, which are not decoded, via the return link. By using the method provided by the invention, the optimal free degree performance based on the closed solution can be acquired under the condition of the relatively low computation complexity, and the return cost can beeffectively reduced.