The invention provides a scheduling main station and an interaction method for the scheduling main station and transformer substations. The interaction method comprises the following steps that: firstly, the scheduling main station sends an inquiry request to a domain management server to inquire transformer substation pre-registered on the domain management server; then, the scheduling main station is connected to corresponding transformer substations, the services provided by which meet requirements of the scheduling main station, and acquires practical engineering configuration files of thetransformer substations; and finally, the scheduling main station analyzes the practical engineering configuration files of the transformer substations and executes the services to be completed by the transformer substations, thus realizing interaction between the scheduling main station and the transformer substations. The interaction process is simple and is favorable for operation. Furthermore, by inquiring the transformer substation information from the domain management server pre-registered with the transformer substation information and acquiring the practical engineering configurationfiles set on the transformer substations, transformer substation-based forwarding tables are no longer needed in the process of the interaction between the scheduling main station and the transformersubstations, and manual configuration is not required, either; and furthermore, the performance requirement for the scheduling main station is lowered.