The invention discloses macromolecule nano waterproof maishi paint with ultra stain resistance and easiness in being cleaned and belongs to the technical field of coating. The maishi paint is preparedfrom the following ingredients in parts by weight: 100 parts of deionized water, 2 parts of defoaming agent, 1.5 parts of hydroxyethyl cellulose, 0.7 part of modified bentonite, 4 parts of ethylene glycol, 0.4 part of multifunctional modifier, 200 to 250 parts of dedicated acrylic acid modified emulsion, 8 to 10 parts of dodecyl alcohol ester, 30 to 50 parts of ultra nano water-free antifoulant,150 to 200 parts of coarse natural color sand, 350 to 450 parts of fine natural color sand, 0.5 part of preservative, 2 parts of mould-proof antibacterial agent and 3 parts of ultraviolet absorber, wherein the sum of the coarse natural color sand and the fine natural color sand is 500 to 650 parts. The invention further discloses a preparation method and a construction method of the maishi paint.After construction of the maishi paint disclosed by the invention, a wall face has the advantages of attractiveness and integrity, and the whole wall body has the advantages of strong waterproof and anticorrosion effects, economic property and reasonability.