The invention provides a positioning and drilling device for industrial machine mounting. The positioning and drilling device for industrial machine mounting comprises a hollow column, a drill rod, anelectric push rod, a sliding block, a mounting block, a damping spring and a buffer plate, the hollow column is assembled in a sleeve, the hollow column is connected with the sleeve through the sliding block, the drilling rod is welded to the lower end face of the mounting block, the electric push rod is fixed to the left in the rack through a screw, the sliding block is assembled in the sleeve through a sliding groove, the mounting block is welded to the lower end of a thread rod, the damping spring is fixed to the annular side face of the hollow column, and the buffer plate is arranged in the hollow column through the damping spring. Through the design, use is convenient, labor intensity is reduced, safety is good, and adjusting is convenient; the device is convenient to use, labor intensity is reduced, safety is good, adjusting is convenient, and reliability is high.