The invention relates to a combined medicine for relaxing a perineal acupoint and a preparation method and application thereof, and belongs to the technical field of female health-care medicines. According to the combined medicine for relaxing the perineal acupoint and the preparation method and application thereof, the combined medicine comprises polygonum cuspidatum, astragalus membranaceus, phellodendron amurense, aloe, radix sophorae flavescentis, radix stemonae, a PH buffering agent, acetyl hexapeptide-8, acetyl tetrapeptide-5, fructus cnidii, chlorhexidine acetate and deionized water, and further comprises couch grass and borneol cinnamomum camphora as a medicinal initiator. According to the combined medicine for relaxing the perineal acupoint and the preparation method and application thereof, the combined medicine has the functions of removing odor, sterilizing, relieving itching, quickly repairing damage, promoting cell regeneration, nourishing the ovary, relaxing the perinealacupoint and facilitating use.