The invention discloses a vertical oil mist purification device, which comprises a cabinet body, wherein a horizontal partition plate is arranged in the cabinet body, the interior of the cabinet bodyis divided into upper and lower cases by the horizontal partition plate, the upper case is provided with a vertical partition plate and is divided into a flue region and a purification region by the vertical partition plate, the purification region is provided with a rotating mesh plate, a first filter screen, an electrostatic filter, a second filter screen, a fan, a third filter screen, a ventilation mesh plate and an air outlet in sequence from bottom to top, the rotating mesh plate is fixedly arranged on the horizontal partition plate, and the first and second filter screens are fixedly arranged at the bottom part and the top part of the electrostatic filter respectively. According to the vertical oil mist purification device, particles, volatilized into the air by collision, of metal cooling oil and metal cutting fluid in a machining workshop can be effectively removed, and influence of the particles on a worker and production equipment in the workshop can be avoided.