The invention relates to a base fertilizer compound fertilizer and application thereof, in particular to a mixed compound fertilizer utilizing domestic sludge and sewage and application of the mixed compound fertilizer and belongs to the technical field of bio-fertilizers. The base fertilizer compound fertilizer is prepared from waste soybeans, waste wheat, waste sorghum, waste corns, a nitrogen fertilizer, a phosphate fertilizer and fermented domestic sludge and sewage and is prepared by fully mixing the components. By adopting the base fertilizer compound fertilizer to apply the fertilizer to soils, the fertilizer application amount is 40-60 catty/mu. By adopting the base fertilizer compound fertilizer, the domestic sludge and sewage are fermented with high-temperature treatment, and worm eggs and pathogenic microorganisms can be killed, so that a finished product reaches harmlessness; and by being mixed and used by matching with the waste soybeans, the waste wheat, the waste sorghumand the waste corns, a fertilizer containing rich humus can be prepared, and the finished fertilizer is stable in fertilizer efficiency, is not rotted and does not smell bad.