The invention belongs to the technical field of ground foundation engineering, and relates to an anti-floating device with an open prestress high-strength concrete pipe pile and an anti-floating anchor rod being integrated. One end of a GFRP anti-floating anchor rod body locator is bound onto a GFRP anti-floating anchor rod body, and the other end of the GFRP anti-floating anchor rod body locatoris bound onto a reserved hole of an annular steel plate; a fixed support seat is installed on a smooth ground; a centering support is installed on the GFRP anti-floating anchor rod body and connectedwith the open prestress high-strength concrete pipe pile; a circular hole provided with a thread on the inner wall is reserved in the center of an enlarged head; the enlarged head is installed on theouter surface of the top end of the GFRP anti-floating anchor rod body and poured in a base bottom plate; a circular steel plate is placed in the open prestress high-strength concrete pipe pile; an inverted-L-shaped steel bar is welded to the circular steel plate; a cushion layer is laid on the ground; and the base bottom plate is arranged on the cushion layer. The anti-floating device with open prestress high-strength concrete pipe pile and the anti-floating anchor rod being integrated is simple in structure, rapid, simple and convenient to install, high in operability, energy-saving and environment-friendly, remarkable in economic benefit and social benefit, and capable of reducing construction procedures for independently producing the anti-floating anchor rod, shortening the working period, and lowering the cost.