The invention belongs to the organic synthesis, and discloses neighbored dispiro-oxoindole compounds with optical activity. The compounds have a formula represented in the description, and in the formula, X represents a NR5, O, or S substituent. The compounds are a white or light yellow solid, has thermodynamic stability and high optical purity, which is not less than 85%, also has antitumor activity, and can inhibit human liver cancer cells, lung cancer cells, and breast cancer cells.