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发明公开
CN108690134A 用于治疗乙肝感染及相关疾病的抗体 有权

用于治疗乙肝感染及相关疾病的抗体
摘要：
本发明涉及抗乙肝表面抗原(HBsAg)的抗体(特别是人源化抗体)，编码它们的核酸分子，制备它们的方法，以及包含它们的药物组合物。此外，本发明还涉及所述抗体和药物组合物的用途。本发明的抗体和药物组合物可用于预防和/或治疗HBV感染或与HBV感染相关的疾病(例如乙肝)，用于在受试者(例如人)体内中和HBV的毒力，或用于在受试者体内降低HBV DNA和/或HBsAg的血清水平。
摘要（英）：

The present invention relates to antibodies (particularly humanized antibodies) against hepatitis B surface antigen (HBsAg), nucleic acid molecules encoding the antibodies, methods for preparing the antibodies, and pharmaceutical compositions containing the antibodies. Furthermore, the invention relates to use of the antibodies and the pharmaceutical compositions. The antibodies and pharmaceuticalcompositions are useful for preventing and/or treating HBV infection or hepatitis B infection and related diseases (such as hepatitis B), for neutralizing the virulence of HBV in a subject (such as ahuman), or for reducing serum levels of HBV DNA and/or HBsAg in the subject.

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