The embodiment of the invention discloses a fatigue driving early-warning method and device, and the method comprises the steps: acquiring current time information and physiological parameter information of a target user when the target user is detected to start a vehicle; determining reference driving time according to the current time information and the physiological parameter information; anddetermining whether the user performs fatigue driving or not according to the reference driving time. According to the technical scheme of the embodiment of the invention, the method and system achieve a purpose that the fatigue driving duration corresponding to the target user can be determined in advance according to the personal information data of the target user and the path information of the target location; the method and system achieve the timely promote for the user through the judging of the relation between the current driving duration and fatigue driving, and improve the technicaleffect of the safety and reliability of driving for the user.