The invention provides an intelligent temperature-humidity measurement and control device of a control cabinet of a transformer station. The device comprises a temperature and humidity detection module, a semiconductor heating and cooling module, a ventilation and dehumidification module, a remote transmission module and a remote monitoring terminal all installed in the control cabinet. The temperature and humidity detection module, the semiconductor heating and cooling module and the ventilation and dehumidification module are in communication connection with the remote monitoring terminal via the remote transmission module, and the remote monitoring terminal controls heating/cooling of the semiconductor heating and cooling module as well as operation of the ventilation and dehumidification module according to temperature and humidity detection parameters of the control cabinet. Thus, the internal temperature and humidity of the control cabinet as well as conditions of a temperature controller, a heater and ventilation and dehumidification equipment can be monitored in real time remotely, temperature controllers in the distributed control cabinet in the station are controlled in aconcentrated way via semiconductor cooling and heating technologies, and when the temperature/humidity in the cabinet is abnormal or the device has adverse condition, the device raises the alarm, andan operation staff is prompted to make tour inspection timely.