The invention discloses an emission inventory processing method of a city-scale high-resolution model based on a SMOKE model, which comprises the following steps: S1, acquiring emission inventory data; S2, generating a template according to the data requirements of the SMOKE model; S3, converting the template generated in the step S2 to the format required by the SMOKE mode; S4: consolidation of combing of multiple emission inventory files; 5, establishing an administrative division code file; S6: correction of the use of the CMAQ model in inland areas requiring the mandatory provision of waveemission documents; S7, generating a KML tag file of point source emission data; S8, creating a SMOKE model run script that matches the urban emission inventory and merging it into the four-dimensional X-Y-Z-T emissions NetCDF format emission data. The invention can meet various scientific research and business requirements based on air quality model, such as pollution source analysis, control measure assessment, environmental impact assessment and the like.