The invention provides a prediction control method of a long-term voltage stabilization model of an alternating current and direct current system. The method comprises steps of S1: based on real-timemeasurement data, determining operation states of the current alternating current and direct current power grid; S2: predicting operation tracks of the alternating current and direct current power grid and acquiring track sensitivity of the voltage by each control quantity; S3: solving the optimal control sequence of the prediction control of the long-term voltage stabilization model of the alternating current and direct current system; and S4: using the optimal control sequence, carrying out rolling optimization control until a control target is met. According to the invention, by applying the prediction control of the long-term voltage stabilization model into the alternating current and direct current system, cooperative control is performed on control quantity of the alternating current and direct current system.