The invention relates to a portable shock-absorbing multifunctional comprehensive medical kit which comprises side plates, a base plate and a cladding plate. The side plates are arranged on two sidesof the base plate, the cladding plate is composed of plate blocks corresponding to three sides except the side plates and the base plate of the medical kit, the side plates are provided with sunken zones, a plurality of upspring frames are arranged in the sunken zones and are used for fixing infusion needles, a main supporting frame and four auxiliary supporting frames are arranged on the base plate and are connected with medicine frames, the main supporting frame is arranged at the central position of the base plate and comprises a cross-shaped base and a cross-shaped fixing clamp, a spherical hole groove is formed in the base, a spherical connector is arranged at the center of the base plate, the spherical connector is connected with the spherical hole groove, the auxiliary supporting frames are arranged at four corners of the base plate and comprise square bases, pipe-type clamps and elastic shafts, the pipe-type clamps are arranged on the upper surfaces of the square bases, and theelastic shafts are connected with the base plate and the square bases.