The invention discloses a multibranched drug conjugate or pharmaceutically acceptable salts thereof, wherein the multibranched drug conjugate has a structural formula shown as (I). The formula is shown in the description. R is an organic center, POLY is a polymer, L is a multivalent junction, T is a targeting molecule, D is an active agent, q is any integer between 3 and 8, wherein the formula ofL is shown in the description. The symbol * represents a linking point between the multivalent junction L and the target molecule T, # represents a linking point between the multivalent junction L andthe active agent D, and % represents a linking point between the multivalent junction L and the POLY; l is any integer between 2 and 20, m and n are respectively any integer between 0 and 10, T is GE11 and D is a camptothecin drug. The conjugate disclosed by the invention, compared with small molecule anticancer compounds, has higher inhibiting ability to tumors and is suitable for solid tumor types such as colon cancer, breast cancer, ovarian cancer, pancreatic cancer, gastric cancer, glioma, malignant sarcoma of breast, ovary, colon, kidney, bile duct, lung and brain as well as cancer and lymphoma.