The invention discloses a multipoint positioning numerical control machine tool with high precision laser, and mainly relates to the field of machine tools. The multipoint positioning numerical control machine tool with the high precision laser comprises a machine tool body, wherein the machine tool body comprises a front table, a workbench, a stand column and a drill rod assembly, and further comprises a clamp assembly, an actuating device assembly rotating along the X-direction axis, an actuating device assembly rotating along the Y-direction axis and a laser angle positioning device. The clamp assembly comprises a clamp base plate, a sliding clamping plate, a bracket fixed block and servo hydraulic cylinders. The actuating device assembly rotating along the X-direction axis comprises adevice support plate, a bearing seat, a first servo motor and a fixed shaft. The laser angle positioning device comprises an angle measuring block and a laser positioning sliding block, wherein the angle measuring block is arranged on the workbench. The multipoint positioning numerical control machine tool with the high precision laser has the beneficial effects that the problems presented in thebackground technology can be solved, cutting inclined angle positioning can be carried out conveniently through the clamping positioning of a complete set of tooling and numerical control controllingof work piece rotation, and a ring array with six grooves or a ring array with eight grooves of numerical control milling is further realized.