The invention discloses a waterproof and portable document storage device for office work. The waterproof and portable document storage device comprises a chassis. Bottom rods are arranged on the leftside and the right side of the lower end of the chassis correspondingly. Sleeve blocks are arranged at the lower ends of the bottom rods and slidably connected with sleeve columns. The lower ends ofthe sleeve blocks are fixedly connected with the sleeve columns through universal wheel springs. Universal wheels are arranged at the lower ends of the sleeve columns. Fixing plugs are mounted on theuniversal wheels. A box is arranged at the upper end of the chassis and internally provided with a waterproof layer. Containing boxes are arranged on the lower portion of the inner side of the waterproof layer. When the waterproof and portable document storage device works, through a ventilating device, air circulating is promoted, and redundant water can also be absorbed by activated carbon in plate grooves; a ratchet wheel mechanism drives rotation of a supporting column, so that storage boxes rotate; and when the waterproof and portable document storage device works, the box moves in all directions conveniently through the universal wheels at the bottom, documents can be classified through the storage boxes, important documents such as portfolios can be stored between partition plates on the lower portion, the containing boxes are arranged at the bottom, and the one-object multi-use effect is achieved.