The embodiment of the invention discloses an automobile seat headrest with an air purification function and an automobile with the automobile seat headrest. The headrest comprises a headrest body andan air purification device. An installation hole is formed in the headrest body. The air purification device comprises a shell frame, a purification module and a power module, wherein the purificationmodule and the power module are arranged in the shell frame. The air purification device is arranged in the installation hole, and the shell frame is cooperatively connected with the installation hole. An automobile seat is provided with a seat power interface, and the power module is connected with the seat power interface and supplies power to the purification module. By the adoption of the automobile seat headrest and the automobile with the automobile seat headrest, the problem that an automobile-mounted air purifier is instable in installation is solved, the automobile-mounted air purifier can be reasonably arranged in the headrest, and the air volume of the purifier can be guaranteed; a wireless module is arranged to communicate with the outside so that the air purification device can be conveniently controlled; and the automobile seat headrest can be exchanged with a common automobile seat headrest, an intra-automobile air purification purpose is achieved, and meanwhile no intra-automobile space is occupied.