The invention provides a novel cold-heat exchange device comprising a plasma power source, an electric core heat transfer piece, heat exchange plates and an energy accumulation reserving plate. The plasma power source converts an alternating current into a direct current to provide a work power source for the electric core heat transfer piece. The electric core heat transfer piece is a semiconductor refrigeration sheet. After the current passes through the electric power core heat transfer piece, the electric core heat transfer piece converts electric energy into heat energy to release heat tothe two sides of the plate or absorb heat. The upper side of the electric core heat transfer piece is in tight contact and connection with the heat transfer plates, the lower side of the electric core heat transfer piece is in tight contact and connection with the energy accumulation reserving plate. Each heat exchange plate is provided with a water inlet, a water outlet and a heat exchange cavity. After the heat exchange medium enters the heat exchange cavity to conduct heat exchange via the water inlet, the heat exchange medium flows out from the water outlet. The energy accumulation reversing plate conducts heat exchange with the lower side of the electric core heat transfer piece and stores heat energy or cold energy. The novel cold-heat exchange device has the advantages of being free of pollution, discharge and noise, easy to operate and practical.