An on-body sensor system includes a hub configured to be attached to a surface of a user. The hub being further configured to transmit electrical power and data signals into the surface and to receive response data signals from the surface. The system further including at least one sensor node configured to be attached to the surface or just below the skin. The system further including at least one sensor node being further configured to receive the electrical power and data signals from the hub through the surface and to transmit the response data signals into the surface. The electrical power from the hub powers the at least one sensor node and causes the at least one sensor node to generate sensor information that is transmitted back to the hub within the response data signals.