The invention relates to a caulis akebiae and dragon's blood plaster and a preparation method thereof. The caulis akebiae and dragon's blood plaster is prepared from the following twelve types of crude drugs of caulis akebiae, dragon's blood, and the like according to a proper proportional ratio by weight; according to the antures, channel tropism, functions, main treatment effects and propertiesof the crude drugs, the monarch drug, ministerial drug, adjuvant drugs and conductant drugs are mutually cooperated, so as to reach the functions of activating blood and removing blood stasis as wellas eliminating swelling and relieving pain; the effects of treating both symptoms and root causes as well as strengthening body resistance and eliminating evil are realized, and various traumatic injuries and the closed fracture after manual reduction can be healed. The caulis akebiae and dragon's blood plaster has the advantages that an external plaster with convenient use effect is provided; theinjury to the human body by the internally taken medicines in the prior art is avoided, and a patient which is not suitable for operation is helped to rehabilitate, thereby solving the pain of the patient; the treatment effect is obvious and stable, the recurrence after medicine stopping is avoided, and any toxic or side effect is avoided.