The invention discloses a medical wet mixing granulator having a heating function. The medical wet mixing granulator comprises a base, a granulating mechanism, a mixing mechanism, a pulping mechanismand a control mechanism are installed on the base, a feed port of the granulating mechanism is connected with a discharge port of the mixing mechanism through a first discharge mechanism, the first discharge mechanism comprises a discharge pipeline and a first conveying pipe, a discharge cavity is arranged in the inner part of the discharge pipeline, a piston column is connected in the discharge cavity in a sliding way, a limiting rod is further fixedly installed in the discharge cavity, a limiting cavity matched with the limiting rod is axially arranged on the piston column, the limiting rodis inserted into the piston column, a ball rotating freely is embedded in the limiting rod, a limiting sliding groove matched with the ball and distributed spirally is arranged in the inner wall of the limiting cavity of the piston column, and a plurality of scraping sheets are fixedly connected at one end near to a discharge nozzle of the piston column. The medical wet mixing granulator solves the problems that the particle granularity is often not even in the granulating process and the discharging is not thorough because a particle sample is easily dipped and stuck on the discharge pipelinein the discharging.