The invention relates to an intelligent debugging and calibration system of an ultra-high voltage isolation switch based on a laser measurement technology. The calibration system comprises a laser measurement sampling device, a mathematical modeling system and an expert analysis decision system, wherein the mathematical modeling system and the analysis system are installed in a debugging computer;the laser measurement sampling device collects various position parameters of a target isolation switch in a space coordinate system; the mathematical modeling system establishes a mathematical modelof the isolation switch space by using the position parameters collected by the laser sampling device; and the expert analysis decision system compares the actual mathematical model of the isolationswitch to be debugged with a standard spatial position model of the isolation switch stored in a database and gives an error and calibration scheme. Compared with the prior art, the ultra-high voltageisolation switch intelligent debugging and calibration system has the following advantages: the debugging process is completed in one step, the work efficiency is improved, and the debugging accuracyis improved.