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发明公开
CN108802361A 一种四碘甲状腺原氨酸酶结合物的制备方法 无效 - 撤回

一种四碘甲状腺原氨酸酶结合物的制备方法
摘要：
本发明涉及一种四碘甲状腺原氨酸酶结合物的制备方法。该方法采用四碘甲状腺原氨酸衍生物（T4‑NHS）直接与酶进行交联结合而成，不需要额外添加活化剂和偶联剂。所述四碘甲状腺原氨酸衍生物为N‑羟基琥珀酰亚胺(NHS)和四碘甲状腺原氨酸的化学合成物质，或为N‑磺酸化羟基琥珀酰亚胺(Sulfo‑NHS)和四碘甲状腺原氨酸的化学合成物质，该方法操作简单，成本低廉，稳定性好。
摘要（英）：

The invention relates to a preparation method of a tetraiodothyronine enzyme conjugate. According to the method, a tetraiodothyronine derivative (T4-NHS) is directly cross-linked with an enzyme to form the conjugate, and no extra activator or coupling agent is added. The tetraiodothyronine derivative is a chemical synthetic substance of N-hydroxysuccinimide (NHS) and tetraiodothyronine, or a chemical synthetic substance of N-sulfonated hydroxysuccinimide (Sulfo-NHS) and tetraiodothyronine. The preparation method is simple to operate, low in cost and good in stability.

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