The invention relates to a fault detection method and system for a COB splicing wall, computer equipment and a computer storage medium. The fault detection method for the COB splicing wall comprises:detecting the number of receiving cards respectively mounted on each network port of the current COB splicing wall, and determining a network port and receiving card mounting relationship of the number of receiving cards corresponding to each network port; comparing the network port and receiving card mounting relationship with the network port and receiving card configuration relationship of theCOB splicing wall, wherein the network port and receiving card configuration relationship records the number of receiving cards configured in each network port of the COB splicing wall; and if the number of receiving cards corresponding to any network port in the network port and receiving card mounting relationship is inconsistent with the number of receiving cards corresponding to the network port in the network port and receiving card configuration relationship, determining that the COB splicing wall has a fault. Based on accurate detection on the fault of the COB splicing wall, the methodand the system have high detection efficiency.