The invention discloses an OLED screen body of a fuse-type short-circuit prevention structure, and a screen body drive circuit for providing a compensating current for the OLED screen body when the OLED screen body is short-circuited to burn a short-circuit point, and returning the current to a normal value when the short-circuit point is burnt down. The drive circuit comprises a power supply circuit for supplying power to the OLED screen body, a current compensation circuit for supplementing a current to the OLED screen body, a switching circuit connected between the current compensation circuit and the OLED screen body, and a control circuit. When the control circuit controls the switching circuit to be turned on, the current compensation circuit starts to provide the compensating current for the OLED screen body; when the control circuit controls the switching circuit to be turned off, the current compensation circuit stops the providing of the compensating current for the OLED screen body. The circuit can timely burn down the fuse structure under the condition that the screen body is short-circuited, so as to protect other light emitting regions of the screen body from being affected, and prolong the service life of an OLED product.